Acetyl-L-Carnitine (1000mg)
Pretreatment with Acetyl-L-Carnitine (ACL) has been demonstrated to exert “effective neuroprotection against the induced neurotoxicity at the mitochondrial level, reducing carbonyl formation, decreasing mtDNA deletion, improving the expression of the respiratory chain components and preventing the decrease of 5-HT levels in several regions of the rat brain.”
Alpha Lipoic Acid (1200 mg)
Alpha Lipoic Acid is an antioxidant that has been shown to “fully prevented the serotonergic deficits and the changes in the glial response induced by methylenedioxy-methamphetamine .”
Coenzyme Q10 (200 mg)
CoQ10 (ubiquinone) “attenuated the depletion of 5-HT in the striatum and hippocampus produced by the systemic administration of methylenedioxy-methamphetamine ”
Vitamin C (500mg)
“Treatment of rats with ascorbic acid suppressed the generation of hydroxyl radicals, as evidenced by the production of 2,3-dihydroxybenzoic acid from salicylic acid, in the striatum during the administration of a neurotoxic regimen of methylenedioxy-methamphetamine . Ascorbic acid also attenuated the methylenedioxy-methamphetamine -induced depletion of striatal 5-HT content.”
Vitamin E (536 mg)
Vitamin E deficiency has been shown to increase the severity of induced neurotoxicity.
Green Tea Extract with EGCG (200 mg)
Green Tea contains powerful antioxidants to protect against free radical damage and avoid urinary retention caused by methylenedioxy-methamphetamine
Melatonin (5 mg)
5 mg is a larger dose than normal for before bed. But for these purposes, it is being utilized for antioxidant properties Melatonin as an antioxidant: biochemical mechanisms and pathophysiological implications in humans
