ALA is a powerful antioxidant that has been shown, in a seminal MDMA neurotoxicity study, to afford “complete protection against MDMA-induced damage” to rodents. In that study, rats were given 20mg of MDMA per kg of body weight – that is over 10x the amount that rollsafe recommends people take. The authors note that ALA “has been shown to protect against excitotoxicity, ischemia-reperfusion injury, mitochondrial dysfunction and other acute or chronic damage to neural tissue involving free radical formation.” And while ALA did not help the rodents keep a lower body temperature (they still experienced hyperthermia from the large doses), “it fully prevented the serotonergic deficits and the changes in the glial response induced by MDMA”.